CD45 -> CD45
CD8 -> CD8
TCRlig -> TCRlig
TCRlig -> TCRbind
cCbl -| TCRbind
TCRbind -| PAGCsk
CD45 -> LCK
CD8 -> LCK
PAGCsk -| LCK
CD45 -> Fyn
TCRbind -> Fyn
LCK -> Fyn
ZAP70 -> cCbl
TCRbind -> TCRphos
LCK -> TCRphos
Fyn -> TCRphos
LCK -> Rlk
LCK -> ZAP70
cCbl -| ZAP70
TCRphos -> ZAP70
ZAP70 -> LATphosp
LATphosp -> Gads
ZAP70 -> Itk
Slp76 -> Itk
PLCg_act_ -> IP3
IP3 -> Ca_
Ca_ -> Calcin
Calcin -> NFAT
CREB -> CRE
Fos -> AP1
Jun -> AP1
IkB -| NFkB
Rsk -> CREB
ERK -> Rsk
MEK -> ERK
ERK -> Fos
JNK -> Jun
Raf -> MEK
Ras -> Raf
Grb2Sos -> Ras
RasGRP1 -> Ras
LATphosp -> Grb2Sos
Gads -> Slp76
LATphosp -> PLCg_bind_
Rlk -> PLCg_act_
ZAP70 -> PLCg_act_
Itk -> PLCg_act_
Slp76 -> PLCg_act_
PLCg_bind_ -> PLCg_act_
PLCg_act_ -> DAG
DAG -> PKCth
DAG -> RasGRP1
PKCth -> RasGRP1
IKKbeta -| IkB
PKCth -> IKKbeta
SEK -> JNK
PKCth -> SEK
$AP1: (Fos & Jun)
$CD45: CD45
$CD8: CD8
$CRE: CREB
$CREB: Rsk
$Ca_: IP3
$Calcin: Ca_
$DAG: PLCg_act_
$ERK: MEK
$Fos: ERK
$Fyn: (((CD45 & !TCRbind) & LCK) | (CD45 & TCRbind))
$Gads: LATphosp
$Grb2Sos: LATphosp
$IKKbeta: PKCth
$IP3: PLCg_act_
$IkB: !IKKbeta
$Itk: (ZAP70 & Slp76)
$JNK: SEK
$Jun: JNK
$LATphosp: ZAP70
$LCK: ((CD45 & CD8) & !PAGCsk)
$MEK: Raf
$NFAT: Calcin
$NFkB: !IkB
$PAGCsk: !TCRbind
$PKCth: DAG
$PLCg_act_: (((((!Rlk & ZAP70) & Itk) & Slp76) & PLCg_bind_) | (((Rlk & ZAP70) & Slp76) & PLCg_bind_))
$PLCg_bind_: LATphosp
$Raf: Ras
$Ras: (Grb2Sos & RasGRP1)
$RasGRP1: (DAG & PKCth)
$Rlk: LCK
$Rsk: ERK
$SEK: PKCth
$Slp76: Gads
$TCRbind: (TCRlig & !cCbl)
$TCRlig: TCRlig
$TCRphos: (((!TCRbind & Fyn) | ((TCRbind & !LCK) & Fyn)) | (TCRbind & LCK))
$ZAP70: ((LCK & !cCbl) & TCRphos)
$cCbl: ZAP70